| 12. Jornada | 03.10.2021 | CF América [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | ||||
| 13. Jornada | 17.10.2021 | Pumas UNAM [Sub 18] | - | FC Juárez [Sub 18] | 2:0 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 18] | - | Club Tijuana [Sub 18] | 2:2 | ||||
| 16. Jornada | 30.10.2021 | CF Pachuca [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | ||||
| 11. Jornada | 04.11.2021 | Pumas UNAM [Sub 18] | - | Santos Laguna [Sub 18] | 0:1 |
México