| 1. Jornada | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 |  |
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| 2. Jornada | 30.07.2021 | FK Lviv | - | Shakhtar Donetsk | 0:3 | ||||
| 3. Jornada | 08.08.2021 | Vorskla Poltava | - | FK Lviv | 4:1 | |
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| 4. Jornada | 15.08.2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 5. Jornada | 23.08.2021 | FK Lviv | - | Inhulets Petrove | 1:2 | ||||
| 6. Jornada | 29.08.2021 | Rukh Lviv | - | FK Lviv | 1:0 | ||||
| 7. Jornada | 13.09.2021 | NK Veres | - | FK Lviv | 1:0 | |
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| 8. Jornada | 19.09.2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | ||||
| 9. Jornada | 26.09.2021 | FC Mynai | - | FK Lviv | 1:2 | ||||
| 10. Jornada | 02.10.2021 | FK Lviv | - | SK Dnipro-1 | 0:1 | ||||
| 11. Jornada | 16.10.2021 | FK Lviv | - | Dinamo Kiev | 1:4 |  |
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| 12. Jornada | 23.10.2021 | Chernomorets Odessa | - | FK Lviv | 1:1 | ||||
| 13. Jornada | 31.10.2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | ||||
| 15. Jornada | 20.11.2021 | FK Lviv | - | Zorya Lugansk | 2:1 | ||||
| 17. Jornada | 03.12.2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 |
Croacia