| 14. Jornada | 27.11.2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
| 15. Jornada | 05.12.2021 | Go Ahead Eagles | - | FC Twente | 1:2 | ||||
| 17. Jornada | 19.12.2021 | Go Ahead Eagles | - | NEC Nijmegen | 0:2 | ||||
| 18. Jornada | 23.12.2021 | PSV | - | Go Ahead Eagles | 2:0 | ||||
| 19. Jornada | 15.01.2022 | Go Ahead Eagles | - | RKC Waalwijk | 0:2 | ||||
| 21. Jornada | 06.02.2022 | FC Groningen | - | Go Ahead Eagles | 2:1 | ||||
| 22. Jornada | 13.02.2022 | Go Ahead Eagles | - | AZ Alkmaar | 1:4 |
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