| 1. Jornada | 13.09.2021 | Progreso | - | Villa Española | 1:1 | ||||
| 2. Jornada | 18.09.2021 | Villa Española | - | Sud América | 1:2 | ||||
| 3. Jornada | 25.09.2021 | Plaza Colonia | - | Villa Española | 4:0 | ||||
| 4. Jornada | 02.10.2021 | Villa Española | - | Fénix | 1:2 |  |
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| 5. Jornada | 10.10.2021 | Boston River | - | Villa Española | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 7. Jornada | 20.10.2021 | Rentistas | - | Villa Española | 3:1 | ||||
| 8. Jornada | 24.10.2021 | Villa Española | - | Peñarol | 1:3 | ||||
| 9. Jornada | 31.10.2021 | Montevideo City Torque | - | Villa Española | 5:0 | ||||
| 10. Jornada | 02.11.2021 | Deportivo Maldonado | - | Villa Española | 0:1 | ||||
| 11. Jornada | 07.11.2021 | Villa Española | - | Nacional | 1:2 | ||||
| 12. Jornada | 13.11.2021 | Cerrito | - | Villa Española | 1:0 | ||||
| 13. Jornada | 19.11.2021 | Villa Española | - | Liverpool | 0:3 | ||||
| 14. Jornada | 30.11.2021 | River Plate | - | Villa Española | 4:2 | ||||
| 15. Jornada | 05.12.2021 | Villa Española | - | Cerro Largo | 1:1 |
Uruguay