| 1. Jornada | 13.09.2021 | Progreso | - | Villa Española | 1:1 | ||||
| 2. Jornada | 19.09.2021 | Nacional | - | Progreso | 0:1 |  |
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| 3. Jornada | 26.09.2021 | Progreso | - | Cerrito | 0:1 |  |
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| 4. Jornada | 03.10.2021 | Liverpool | - | Progreso | 0:1 | ||||
| 5. Jornada | 09.10.2021 | Progreso | - | River Plate | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 7. Jornada | 21.10.2021 | Progreso | - | Deportivo Maldonado | 2:0 | |
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| 8. Jornada | 25.10.2021 | Progreso | - | Sud América | 0:0 | ||||
| 9. Jornada | 30.10.2021 | Plaza Colonia | - | Progreso | 2:1 | ||||
| 10. Jornada | 04.11.2021 | Progreso | - | Fénix | 1:0 | |
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| 11. Jornada | 08.11.2021 | Boston River | - | Progreso | 0:0 | ||||
| 12. Jornada | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 | |
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| 13. Jornada | 21.11.2021 | Rentistas | - | Progreso | 0:1 | |
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| 14. Jornada | 25.11.2021 | Progreso | - | Peñarol | 0:0 | ||||
| 15. Jornada | 04.12.2021 | Montevideo City Torque | - | Progreso | 1:0 |
Uruguay