| 1. Jornada | 25.04.2021 | Louisville City FC | - | Atlanta United II | 2:0 | ||||
| 2. Jornada | 30.05.2021 | Louisville City FC | - | Indy Eleven | 1:2 | ||||
| 4. Jornada | 03.07.2021 | Sporting Kansas City 2 | - | Louisville City FC | 2:4 |  |
|||
| 4. Jornada | 15.07.2021 | Louisville City FC | - | OKC Energy FC | 3:1 | ||||
| 4. Jornada | 18.07.2021 | Louisville City FC | - | Atlanta United II | 2:0 | ||||
| 4. Jornada | 01.08.2021 | Louisville City FC | - | OKC Energy FC | 2:1 | ||||
| 6. Jornada | 04.09.2021 | Louisville City FC | - | FC Tulsa | 0:1 | ||||
| 6. Jornada | 13.09.2021 | OKC Energy FC | - | Louisville City FC | 1:1 | |
|||
| 6. Jornada | 30.09.2021 | Atlanta United II | - | Louisville City FC | 1:1 | |
Estados Unidos