| 1. Jornada | 24.07.2021 | Shakhtar Donetsk | - | Inhulets Petrove | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Shakhtar Donetsk | - | FK Oleksandriya | 1:2 | ||||
| 4. Jornada | 13.08.2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 5. Jornada | 21.08.2021 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 |  |
|||
| 6. Jornada | 29.08.2021 | FC Mynai | - | Shakhtar Donetsk | 1:1 | ||||
| 8. Jornada | 18.09.2021 | FK Mariupol | - | Shakhtar Donetsk | 0:5 | |
|||
| 12. Jornada | 23.10.2021 | Vorskla Poltava | - | Shakhtar Donetsk | 0:2 | ||||
| 13. Jornada | 30.10.2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 | |
|||
| 16. Jornada | 28.11.2021 | Inhulets Petrove | - | Shakhtar Donetsk | 0:1 | ||||
| 17. Jornada | 03.12.2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 |
Ucrania