| 1. Jornada | 09.07.2016 | Libertad | - | River Plate | 1:1 |  |
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| 2. Jornada | 17.07.2016 | River Plate | - | General Díaz | 0:0 | ||||
| 3. Jornada | 20.07.2016 | Guaraní | - | River Plate | 2:0 | |
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| 4. Jornada | 25.07.2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 5. Jornada | 02.08.2016 | Club Rubio Ñu | - | River Plate | 5:1 | ||||
| 10. Jornada | 10.09.2016 | Sol de América | - | River Plate | 2:6 | |
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| 11. Jornada | 18.09.2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Jornada | 24.09.2016 | River Plate | - | Libertad | 2:0 | ||||
| 17. Jornada | 05.11.2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 18. Jornada | 19.11.2016 | River Plate | - | Sportivo Luqueño | 0:2 | ||||
| 19. Jornada | 26.11.2016 | River Plate | - | Deportivo Capiatá | 2:4 | |
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| 20. Jornada | 02.12.2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 21. Jornada | 11.12.2016 | River Plate | - | Sol de América | 2:4 | ||||
| 22. Jornada | 18.12.2016 | Club Nacional | - | River Plate | 2:0 | |
Paraguay