| 2. Jornada | 22.08.2021 | St. Luċija FC | - | Gżira United | 1:1 |  |
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| 3. Jornada | 12.09.2021 | Gudja United | - | St. Luċija FC | 2:2 |  |
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| 4. Jornada | 18.09.2021 | St. Luċija FC | - | Sirens FC | 1:3 | |
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| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | |
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| 7. Jornada | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | ||||
| 8. Jornada | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 9. Jornada | 21.11.2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | |
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| 10. Jornada | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Jornada | 05.12.2021 | St. Luċija FC | - | Balzan FC | 3:3 | ||||
| 12. Jornada | 11.12.2021 | St. Luċija FC | - | Floriana FC | 1:3 | ||||
| 13. Jornada | 18.12.2021 | Gżira United | - | St. Luċija FC | 2:2 | |
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| 16. Jornada | 29.01.2022 | St. Luċija FC | - | Hibernians FC | 0:0 | ||||
| 17. Jornada | 05.02.2022 | Mosta FC | - | St. Luċija FC | 1:0 | |
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| 18. Jornada | 13.02.2022 | Sliema Wanderers | - | St. Luċija FC | 1:1 | ||||
| 19. Jornada | 20.02.2022 | St. Luċija FC | - | Valletta FC | 2:1 | ||||
| 20. Jornada | 27.02.2022 | Birkirkara FC | - | St. Luċija FC | 2:3 | ||||
| 21. Jornada | 06.03.2022 | St. Luċija FC | - | Hamrun Spartans | 0:1 | ||||
| 22. Jornada | 11.03.2022 | Balzan FC | - | St. Luċija FC | 0:1 |
Italia