| 1. Jornada | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 |  |
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| 2. Jornada | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 4. Jornada | 29.01.2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
| 13. Jornada | 02.04.2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
| 14. Jornada | 06.04.2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 |
México