| 1. Jornada | 27.03.2010 | Columbus Crew | - | Toronto FC | 2:0 | ||||
| 2. Jornada | 25.04.2010 | Columbus Crew | - | Real Salt Lake | 1:0 | ||||
| 3. Jornada | 09.05.2010 | Columbus Crew | - | New England Revolution | 3:2 | ||||
| 3. Jornada | 16.05.2010 | Columbus Crew | - | CD Chivas | 1:0 | ||||
| 3. Jornada | 23.05.2010 | Kansas City Wizards | - | Columbus Crew | 0:1 |  |
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| 3. Jornada | 30.05.2010 | Columbus Crew | - | Los Angeles Galaxy | 0:2 | ||||
| 4. Jornada | 03.06.2010 | San Jose Earthquakes | - | Columbus Crew | 2:2 | ||||
| 4. Jornada | 06.06.2010 | Colorado Rapids | - | Columbus Crew | 1:0 | ||||
| 4. Jornada | 27.06.2010 | Columbus Crew | - | D.C. United | 2:0 | ||||
| 5. Jornada | 04.07.2010 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 5. Jornada | 11.07.2010 | Houston Dynamo | - | Columbus Crew | 0:0 | |
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| 5. Jornada | 15.07.2010 | Columbus Crew | - | Kansas City Wizards | 0:1 | ||||
| 7. Jornada | 05.09.2010 | D.C. United | - | Columbus Crew | 0:1 | ||||
| 8. Jornada | 09.10.2010 | Chicago Fire | - | Columbus Crew | 2:0 | ||||
| 8. Jornada | 16.10.2010 | Toronto FC | - | Columbus Crew | 2:2 |
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