| 1. Jornada | 06.02.2022 | Guaireña FC | - | Guaraní | 0:0 |  |
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| 2. Jornada | 13.02.2022 | Guaraní | - | Sol de América | 0:1 | |
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| 3. Jornada | 19.02.2022 | Cerro Porteño | - | Guaraní | 2:0 | |
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| 6. Jornada | 13.03.2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 7. Jornada | 20.03.2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 13. Jornada | 01.05.2022 | Sol de América | - | Guaraní | 2:2 | |
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| 14. Jornada | 09.05.2022 | Guaraní | - | Cerro Porteño | 1:2 | |
Argentina
Paraguay