| 7. Jornada | 22.08.2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 | ||||
| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Jornada | 15.09.2022 | Guaraní | - | Sportivo Ameliano | 2:1 | ||||
| 14. Jornada | 04.10.2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 16. Jornada | 13.10.2022 | Guaraní | - | Sol de América | 4:1 | ||||
| 17. Jornada | 17.10.2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Jornada | 13.11.2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay