| 1. Jornada | 21.07.2012 | Club Tijuana | - | Puebla FC | 2:0 |  |
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| 2. Jornada | 29.07.2012 | Puebla FC | - | Deportivo Toluca | 1:3 |  |
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| 4. Jornada | 12.08.2012 | Puebla FC | - | Cruz Azul | 0:1 | ||||
| 5. Jornada | 18.08.2012 | Monarcas Morelia | - | Puebla FC | 3:0 | ||||
| 6. Jornada | 26.08.2012 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 7. Jornada | 03.09.2012 | Deportivo Guadalajara | - | Puebla FC | 1:1 | ||||
| 8. Jornada | 16.09.2012 | Puebla FC | - | CF Monterrey | 2:3 | |
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| 9. Jornada | 22.09.2012 | Puebla FC | - | Club León | 1:1 | ||||
| 11. Jornada | 04.10.2012 | Puebla FC | - | CF Pachuca | 2:0 | ||||
| 12. Jornada | 07.10.2012 | UANL Tigres | - | Puebla FC | 1:2 | ||||
| 14. Jornada | 20.10.2012 | Jaguares Chiapas | - | Puebla FC | 2:0 | |
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| 13. Jornada | 26.10.2012 | Puebla FC | - | CF América | 0:1 | ||||
| 15. Jornada | 28.10.2012 | Puebla FC | - | Atlante | 1:2 |  |
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| 16. Jornada | 04.11.2012 | Atlas Guadalajara | - | Puebla FC | 2:2 |
Paraguay