| 1. Jornada | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Jornada | 15.01.2022 | Puebla FC [] | - | Gallos Blancos [] | 0:0 | ||||
| 5. Jornada | 05.02.2022 | Club Necaxa [] | - | Puebla FC [] | 4:0 | ||||
| 7. Jornada | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 9. Jornada | 05.03.2022 | Puebla FC [] | - | FC Juárez [] | 3:2 | ||||
| 11. Jornada | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | ||||
| 15. Jornada | 16.04.2022 | FC Juárez [] | - | Puebla FC [] | 4:0 | ||||
| 17. Jornada | 30.04.2022 | Puebla FC [] | - | CF América [] | 2:3 |
México