| 2. Jornada | 31.07.2021 | Club León [Sub 20] | - | Club Tijuana [Sub 20] | 2:1 | ||||
| 4. Jornada | 14.08.2021 | Club León [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 |  |
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| 5. Jornada | 18.08.2021 | Deportivo Guadalajara [Sub 20] | - | Club León [Sub 20] | 1:2 | |
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| 6. Jornada | 21.08.2021 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 7. Jornada | 28.08.2021 | Club León [Sub 20] | - | CF América [Sub 20] | 2:2 | ||||
| 8. Jornada | 11.09.2021 | UANL Tigres [Sub 20] | - | Club León [Sub 20] | 2:0 | ||||
| 9. Jornada | 18.09.2021 | Club León [Sub 20] | - | FC Juárez [Sub 20] | 2:0 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 20] | - | Club Necaxa [Sub 20] | 3:1 |
México