| 1. Jornada | 03.07.2022 | Atlético San Luis [Sub 20] | - | Club León [Sub 20] | 1:3 | ||||
| 2. Jornada | 10.07.2022 | Club León [Sub 20] | - | Pumas UNAM [Sub 20] | 3:2 | ||||
| 5. Jornada | 26.07.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 0:0 | ||||
| 6. Jornada | 31.07.2022 | Club León [Sub 20] | - | CF América [Sub 20] | 1:0 | ||||
| 9. Jornada | 18.08.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 2:3 |  |
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| 10. Jornada | 21.08.2022 | CF Pachuca [Sub 20] | - | Club León [Sub 20] | 3:0 | ||||
| 11. Jornada | 28.08.2022 | Club León [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:1 | ||||
| 12. Jornada | 02.09.2022 | Club Necaxa [Sub 20] | - | Club León [Sub 20] | 2:2 | |
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| 13. Jornada | 06.09.2022 | Club León [Sub 20] | - | FC Juárez [Sub 20] | 3:1 | ||||
| 14. Jornada | 10.09.2022 | UANL Tigres [Sub 20] | - | Club León [Sub 20] | 3:2 | ||||
| 16. Jornada | 15.09.2022 | Cruz Azul [Sub 20] | - | Club León [Sub 20] | 1:1 | ||||
| 15. Jornada | 18.09.2022 | Club León [Sub 20] | - | Gallos Blancos [Sub 20] | 3:2 |  |
México