| 4. Jornada | 06.02.2022 | Deportivo Toluca [Sub 20] | - | CF Monterrey [Sub 20] | 3:0 | ||||
| 5. Jornada | 12.02.2022 | CF Monterrey [Sub 20] | - | FC Juárez [Sub 20] | 1:0 | ||||
| 6. Jornada | 18.02.2022 | Puebla FC [Sub 20] | - | CF Monterrey [Sub 20] | 3:0 | ||||
| 7. Jornada | 26.02.2022 | CF Monterrey [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 |  |
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| 9. Jornada | 05.03.2022 | CF Monterrey [Sub 20] | - | CF América [Sub 20] | 3:2 | ||||
| 10. Jornada | 11.03.2022 | CF Monterrey [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 |  |
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| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 20] | - | CF Monterrey [Sub 20] | 0:1 | ||||
| 13. Jornada | 26.03.2022 | CF Monterrey [Sub 20] | - | Santos Laguna [Sub 20] | 1:2 | |
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| 12. Jornada | 02.04.2022 | Deportivo Guadalajara [Sub 20] | - | CF Monterrey [Sub 20] | 2:1 | ||||
| 15. Jornada | 20.04.2022 | CF Monterrey [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:0 | ||||
| 17. Jornada | 30.04.2022 | CF Monterrey [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 |
México