| 6. Jornada | 21.08.2021 | Atlas Guadalajara [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:2 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | ||||
| 8. Jornada | 13.09.2021 | CF Pachuca [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:0 |  |
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| 15. Jornada | 24.10.2021 | Santos Laguna [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:0 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 17. Jornada | 05.11.2021 | Puebla FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 0:3 |
México