| 1. Jornada | 11.01.2025 | Mazatlán FC | - | FC Juárez | 1:1 | ||||
| 2. Jornada | 18.01.2025 | UANL Tigres | - | Mazatlán FC | 2:1 | ||||
| 3. Jornada | 25.01.2025 | Mazatlán FC | - | Deportivo Toluca | 2:1 | ||||
| 4. Jornada | 29.01.2025 | Puebla FC | - | Mazatlán FC | 0:1 | ||||
| 5. Jornada | 01.02.2025 | Mazatlán FC | - | Club León | 1:2 | ||||
| 6. Jornada | 10.02.2025 | Pumas UNAM | - | Mazatlán FC | 1:0 | ||||
| 7. Jornada | 15.02.2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 8. Jornada | 22.02.2025 | Club Necaxa | - | Mazatlán FC | 3:1 |  |
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| 9. Jornada | 26.02.2025 | Mazatlán FC | - | CF Monterrey | 1:0 | ||||
| 10. Jornada | 01.03.2025 | Mazatlán FC | - | Cruz Azul | 1:1 | ||||
| 11. Jornada | 09.03.2025 | CF Pachuca | - | Mazatlán FC | 1:1 | |
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| 12. Jornada | 15.03.2025 | Gallos Blancos | - | Mazatlán FC | 1:0 | |
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| 13. Jornada | 29.03.2025 | Mazatlán FC | - | Atlas Guadalajara | 3:2 | ||||
| 14. Jornada | 06.04.2025 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 15. Jornada | 12.04.2025 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
| 16. Jornada | 17.04.2025 | Mazatlán FC | - | Club Tijuana | 0:2 |
Ecuador