| 2. Jornada | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
| 4. Jornada | 29.01.2022 | UANL Tigres [] | - | Club Tijuana [] | 2:0 | ||||
| 6. Jornada | 12.02.2022 | UANL Tigres [] | - | CF Monterrey [] | 1:0 |  |
|||
| 11. Jornada | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | ||||
| 13. Jornada | 02.04.2022 | UANL Tigres [] | - | Atlético San Luis [] | 2:0 | ||||
| 16. Jornada | 23.04.2022 | Santos Laguna [] | - | UANL Tigres [] | 5:0 | ||||
| 17. Jornada | 30.04.2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 18. Jornada | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
México