| 1. Jornada | 21.08.2021 | Paphos FC | - | APOEL Nikosia | 4:0 |  |
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| 3. Jornada | 18.09.2021 | Paphos FC | - | AEK Larnaca | 1:1 | ||||
| 5. Jornada | 02.10.2021 | Paphos FC | - | Doxa Katokopias | 1:1 | |
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| 6. Jornada | 16.10.2021 | Paphos FC | - | Olympiacos Nikosia | 1:1 | |
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| 7. Jornada | 23.10.2021 | Apollon Limassol | - | Paphos FC | 2:0 | ||||
| 10. Jornada | 20.11.2021 | Paphos FC | - | Ethnikos Achna | 3:0 | ||||
| 11. Jornada | 27.11.2021 | Aris Limassol | - | Paphos FC | 0:0 | ||||
| 12. Jornada | 05.12.2021 | APOEL Nikosia | - | Paphos FC | 1:1 |  |
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| 13. Jornada | 10.12.2021 | Paphos FC | - | AEL Limassol | 1:0 | |
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| 14. Jornada | 20.12.2021 | AEK Larnaca | - | Paphos FC | 1:3 | |
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| 15. Jornada | 05.01.2022 | Paphos FC | - | Omonia Nikosia | 1:1 | ||||
| 17. Jornada | 15.01.2022 | Olympiacos Nikosia | - | Paphos FC | 1:2 | ||||
| 16. Jornada | 18.02.2022 | Doxa Katokopias | - | Paphos FC | 1:1 | |
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| 22. Jornada | 25.02.2022 | Paphos FC | - | Aris Limassol | 1:1 |
Portugal