| 2. Jornada | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 |  |
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| 8. Jornada | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 9. Jornada | 20.11.2021 | Mosta FC | - | Gżira United | 2:2 | ||||
| 10. Jornada | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 12. Jornada | 12.12.2021 | Birkirkara FC | - | Mosta FC | 2:2 | ||||
| 13. Jornada | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | ||||
| 14. Jornada | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Jornada | 22.01.2022 | Mosta FC | - | Hibernians FC | 1:1 | ||||
| 16. Jornada | 29.01.2022 | Balzan FC | - | Mosta FC | 2:3 | ||||
| 17. Jornada | 05.02.2022 | Mosta FC | - | St. Luċija FC | 1:0 |
Malta