| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Jornada | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 | ||||
| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | ||||
| 4. Jornada | 18.09.2021 | Hibernians FC | - | Mosta FC | 3:2 |  |
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| 5. Jornada | 26.09.2021 | Mosta FC | - | Balzan FC | 2:1 | ||||
| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 9. Jornada | 20.11.2021 | Mosta FC | - | Gżira United | 2:2 | ||||
| 10. Jornada | 27.11.2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 12. Jornada | 12.12.2021 | Birkirkara FC | - | Mosta FC | 2:2 |  |
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| 13. Jornada | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | ||||
| 14. Jornada | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 |
Nigeria