| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 |  |
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| 2. Jornada | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 | |
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| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | |
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| 4. Jornada | 18.09.2021 | Hibernians FC | - | Mosta FC | 3:2 | ||||
| 5. Jornada | 26.09.2021 | Mosta FC | - | Balzan FC | 2:1 | ||||
| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Jornada | 23.10.2021 | Mosta FC | - | Floriana FC | 1:1 | |
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| 9. Jornada | 20.11.2021 | Mosta FC | - | Gżira United | 2:2 |  |
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| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 | |
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| 12. Jornada | 12.12.2021 | Birkirkara FC | - | Mosta FC | 2:2 | ||||
| 13. Jornada | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | ||||
| 14. Jornada | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Jornada | 22.01.2022 | Mosta FC | - | Hibernians FC | 1:1 | ||||
| 16. Jornada | 29.01.2022 | Balzan FC | - | Mosta FC | 2:3 | ||||
| 17. Jornada | 05.02.2022 | Mosta FC | - | St. Luċija FC | 1:0 | ||||
| 18. Jornada | 12.02.2022 | Floriana FC | - | Mosta FC | 2:0 | ||||
| 19. Jornada | 20.02.2022 | Mosta FC | - | Sliema Wanderers | 1:0 | |
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| 21. Jornada | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 | ||||
| 22. Jornada | 12.03.2022 | Gudja United | - | Mosta FC | 1:0 |
Camerún