| 1. Jornada | 02.07.2022 | Mazatlán FC | - | Puebla FC | 2:4 |  |
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| 2. Jornada | 09.07.2022 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 3. Jornada | 16.07.2022 | Puebla FC | - | Club León | 1:1 | |
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| 4. Jornada | 24.07.2022 | Cruz Azul | - | Puebla FC | 2:2 |  |
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| 5. Jornada | 27.07.2022 | CF Monterrey | - | Puebla FC | 1:0 | ||||
| 6. Jornada | 31.07.2022 | Puebla FC | - | Atlético San Luis | 0:0 | |
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| 16. Jornada | 03.08.2022 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 8. Jornada | 13.08.2022 | Club Tijuana | - | Puebla FC | 3:3 | ||||
| 9. Jornada | 17.08.2022 | Puebla FC | - | Club Necaxa | 2:2 | |
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| 10. Jornada | 21.08.2022 | Atlas Guadalajara | - | Puebla FC | 1:1 | ||||
| 11. Jornada | 27.08.2022 | Puebla FC | - | FC Juárez | 2:2 | ||||
| 12. Jornada | 02.09.2022 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
| 13. Jornada | 08.09.2022 | Puebla FC | - | CF Pachuca | 2:2 | |
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| 14. Jornada | 11.09.2022 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 15. Jornada | 17.09.2022 | Puebla FC | - | UANL Tigres | 2:1 | ||||
| 7. Jornada | 24.09.2022 | Puebla FC | - | Pumas UNAM | 2:1 | |
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| 17. Jornada | 01.10.2022 | Puebla FC | - | CF América | 1:2 |
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