| 1. Jornada | 17.07.2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 2. Jornada | 22.07.2022 | Guaraní | - | General Caballero DJLM | 2:1 |  |
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| 3. Jornada | 26.07.2022 | Resistencia SC | - | Guaraní | 0:0 | |
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| 4. Jornada | 01.08.2022 | Guaraní | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 5. Jornada | 07.08.2022 | Sol de América | - | Guaraní | 1:0 | |
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| 6. Jornada | 15.08.2022 | Guaraní | - | Club Nacional | 1:1 | ||||
| 7. Jornada | 22.08.2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 | |
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| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Jornada | 15.09.2022 | Guaraní | - | Sportivo Ameliano | 2:1 |  |
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| 12. Jornada | 20.09.2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 14. Jornada | 04.10.2022 | Guaraní | - | Resistencia SC | 0:1 | |
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| 16. Jornada | 13.10.2022 | Guaraní | - | Sol de América | 4:1 | ||||
| 17. Jornada | 17.10.2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 18. Jornada | 23.10.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Jornada | 13.11.2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Argentina