| 2. Jornada | 16.01.2022 | Atlético San Luis [Sub 16] | - | Mazatlán FC [Sub 16] | 1:2 | ||||
| 3. Jornada | 22.01.2022 | Club Tijuana [Sub 16] | - | Atlético San Luis [Sub 16] | 2:0 | ||||
| 4. Jornada | 29.01.2022 | Atlético San Luis [Sub 16] | - | Atlas Guadalajara [Sub 16] | 0:1 | ||||
| 9. Jornada | 05.03.2022 | Atlético San Luis [Sub 16] | - | UANL Tigres [Sub 16] | 1:1 | ||||
| 10. Jornada | 12.03.2022 | Atlético San Luis [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 | ||||
| 12. Jornada | 26.03.2022 | Atlético San Luis [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 |  |
México