| 1. Jornada | 25.06.2022 | Pumas UNAM [] | - | Cruz Azul [] | 3:2 |  |
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| 6. Jornada | 30.07.2022 | Pumas UNAM [] | - | CF Pachuca [] | 1:0 | |
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| 7. Jornada | 06.08.2022 | FC Juárez [] | - | Pumas UNAM [] | 3:4 | |
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| 8. Jornada | 13.08.2022 | Pumas UNAM [] | - | CF América [] | 3:0 | |
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| 9. Jornada | 20.08.2022 | Puebla FC [] | - | Pumas UNAM [] | 1:2 | |
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| 10. Jornada | 27.08.2022 | Cruz Azul [] | - | Pumas UNAM [] | 0:4 | |
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| 11. Jornada | 03.09.2022 | Pumas UNAM [] | - | Gallos Blancos [] | 3:0 | |
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| 12. Jornada | 10.09.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 1:0 | ||||
| 13. Jornada | 17.09.2022 | Pumas UNAM [] | - | Club Necaxa [] | 2:1 | |
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| 15. Jornada | 01.10.2022 | CF Pachuca [] | - | Pumas UNAM [] | 3:3 | |
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| 16. Jornada | 08.10.2022 | Pumas UNAM [] | - | FC Juárez [] | 6:0 | |
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| 17. Jornada | 15.10.2022 | CF América [] | - | Pumas UNAM [] | 2:1 | ||||
| 18. Jornada | 22.10.2022 | Pumas UNAM [] | - | Puebla FC [] | 1:0 |
México