| 2. Jornada | 24.07.2010 | Club Rubio Ñu | - | Sport Colombia | 1:0 | ||||
| 3. Jornada | 01.08.2010 | Sport Colombia | - | Libertad | 1:0 | ||||
| 5. Jornada | 14.08.2010 | Sport Colombia | - | Guaraní | 1:1 | ||||
| 6. Jornada | 21.08.2010 | Sport Colombia | - | Tacuary | 1:3 | ||||
| 7. Jornada | 29.08.2010 | Sport Colombia | - | Club Nacional | 1:2 | ||||
| 8. Jornada | 05.09.2010 | Sol de América | - | Sport Colombia | 1:2 |  |
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| 9. Jornada | 12.09.2010 | Sport Colombia | - | Sportivo Trinidense | 1:1 | ||||
| 10. Jornada | 19.09.2010 | Sportivo Luqueño | - | Sport Colombia | 1:1 | |
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| 11. Jornada | 26.09.2010 | Cerro Porteño | - | Sport Colombia | 0:0 | ||||
| 15. Jornada | 20.10.2010 | Sport Colombia | - | 3 de Febrero | 1:1 | ||||
| 16. Jornada | 24.10.2010 | Guaraní | - | Sport Colombia | 3:0 | ||||
| 17. Jornada | 30.10.2010 | Tacuary | - | Sport Colombia | 2:1 | ||||
| 18. Jornada | 06.11.2010 | Club Nacional | - | Sport Colombia | 4:3 | |
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| 19. Jornada | 14.11.2010 | Sport Colombia | - | Sol de América | 2:0 | ||||
| 20. Jornada | 21.11.2010 | Sportivo Trinidense | - | Sport Colombia | 2:2 | ||||
| 21. Jornada | 28.11.2010 | Sport Colombia | - | Sportivo Luqueño | 0:0 |
Paraguay