| 1. Jornada | 08.01.2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 | ||||
| 4. Jornada | 29.01.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Gallos Blancos [] | - | Pumas UNAM [] | 1:3 | ||||
| 9. Jornada | 05.03.2022 | Pumas UNAM [] | - | Club Necaxa [] | 1:1 | ||||
| 15. Jornada | 23.03.2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 | ||||
| 14. Jornada | 30.03.2022 | Pumas UNAM [] | - | Gallos Blancos [] | 2:1 | ||||
| 18. Jornada | 07.05.2022 | Pumas UNAM [] | - | Puebla FC [] | 2:1 |
México