| 3. Jornada | 22.01.2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 | ||||
| 7. Jornada | 19.02.2022 | FC Juárez [] | - | Cruz Azul [] | 3:1 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [] | - | CF América [] | 3:1 | ||||
| 11. Jornada | 19.03.2022 | Gallos Blancos [] | - | Cruz Azul [] | 4:0 | ||||
| 15. Jornada | 23.03.2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 | ||||
| 12. Jornada | 26.03.2022 | Cruz Azul [] | - | FC Juárez [] | 0:2 | ||||
| 13. Jornada | 02.04.2022 | Cruz Azul [] | - | Deportivo Toluca [] | 1:1 | ||||
| 18. Jornada | 07.05.2022 | Cruz Azul [] | - | Club Necaxa [] | 1:3 |
México