| 1. Jornada | 09.01.2022 | Deportivo Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 | ||||
| 3. Jornada | 21.01.2022 | Mazatlán FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 |  |
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| 4. Jornada | 06.02.2022 | UANL Tigres [Sub 20] | - | Mazatlán FC [Sub 20] | 3:2 | ||||
| 5. Jornada | 11.02.2022 | Mazatlán FC [Sub 20] | - | Club Tijuana [Sub 20] | 0:2 | ||||
| 6. Jornada | 20.02.2022 | Gallos Blancos [Sub 20] | - | Mazatlán FC [Sub 20] | 0:0 | ||||
| 7. Jornada | 24.02.2022 | CF Pachuca [Sub 20] | - | Mazatlán FC [Sub 20] | 3:2 | ||||
| 10. Jornada | 11.03.2022 | CF Monterrey [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 | ||||
| 14. Jornada | 14.04.2022 | Atlas Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 | ||||
| 16. Jornada | 22.04.2022 | FC Juárez [Sub 20] | - | Mazatlán FC [Sub 20] | 3:0 |
México