| 1. Jornada | 24.07.2021 | CF Pachuca [Sub 20] | - | Club León [Sub 20] | 0:1 | ||||
| 2. Jornada | 31.07.2021 | Club León [Sub 20] | - | Club Tijuana [Sub 20] | 2:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 11. Jornada | 03.11.2021 | Cruz Azul [Sub 20] | - | Club León [Sub 20] | 2:0 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 20] | - | Club Necaxa [Sub 20] | 3:1 |  |
México