| 21. Jornada | 05.02.2022 | FC Twente | - | Vitesse | 3:0 | ||||
| 23. Jornada | 20.02.2022 | FC Twente | - | Go Ahead Eagles | 2:2 |  |
|||
| 24. Jornada | 25.02.2022 | RKC Waalwijk | - | FC Twente | 1:2 |  |
|||
| 25. Jornada | 06.03.2022 | FC Twente | - | SC Cambuur | 1:0 | |
|||
| 26. Jornada | 13.03.2022 | AZ Alkmaar | - | FC Twente | 0:1 | |
|||
| 27. Jornada | 19.03.2022 | FC Twente | - | PEC Zwolle | 1:0 | ||||
| 28. Jornada | 02.04.2022 | FC Twente | - | PSV | 3:3 | ||||
| 29. Jornada | 09.04.2022 | NEC Nijmegen | - | FC Twente | 0:2 | ||||
| 30. Jornada | 22.04.2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
| 31. Jornada | 30.04.2022 | Heracles Almelo | - | FC Twente | 1:1 | |
|||
| 32. Jornada | 07.05.2022 | FC Twente | - | Fortuna Sittard | 1:2 | |
|||
| 33. Jornada | 11.05.2022 | FC Twente | - | FC Groningen | 3:0 | ||||
| 34. Jornada | 15.05.2022 | Feyenoord | - | FC Twente | 1:2 |
Países Bajos