| 2. Jornada | 14.08.2021 | FC Breitenrain Bern | - | SC Brühl | 1:0 | ||||
| 4. Jornada | 28.08.2021 | SC Brühl | - | SC YF/Juventus Zürich | 2:5 |  |
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| 9. Jornada | 02.10.2021 | AC Bellinzona | - | SC Brühl | 2:1 | ||||
| 10. Jornada | 09.10.2021 | SC Brühl | - | BSC Young Boys II | 0:3 | ||||
| 11. Jornada | 16.10.2021 | FC Chiasso | - | SC Brühl | 1:1 | ||||
| 12. Jornada | 23.10.2021 | SC Brühl | - | FC Biel/Bienne | 1:1 | |
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| 13. Jornada | 30.10.2021 | FC Basel 1893 II | - | SC Brühl | 1:3 |  |
 |
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| 18. Jornada | 04.12.2021 | FC Rapperswil-Jona | - | SC Brühl | 2:1 | ||||
| 20. Jornada | 26.02.2022 | SC Brühl | - | SC Cham | 2:2 | ||||
| 21. Jornada | 05.03.2022 | FC Black Stars Basel | - | SC Brühl | 2:1 |
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