| 1. Jornada | 08.01.2022 | Cruz Azul [Sub 20] | - | Club Tijuana [Sub 20] | 0:1 | ||||
| 2. Jornada | 15.01.2022 | Cruz Azul [Sub 20] | - | FC Juárez [Sub 20] | 0:0 | ||||
| 10. Jornada | 12.03.2022 | Cruz Azul [Sub 20] | - | Pumas UNAM [Sub 20] | 1:0 | ||||
| 12. Jornada | 02.04.2022 | Cruz Azul [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:0 | ||||
| 13. Jornada | 08.04.2022 | Mazatlán FC [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 14. Jornada | 16.04.2022 | Cruz Azul [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 2:1 | ||||
| 15. Jornada | 21.04.2022 | Gallos Blancos [Sub 20] | - | Cruz Azul [Sub 20] | 1:3 |
México