| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 |  |
|||
| 10. Jornada | 02.04.2021 | Club Nacional | - | Guaraní | 2:0 | ||||
| 11. Jornada | 11.04.2021 | Sol de América | - | Club Nacional | 1:2 | ||||
| 15. Jornada | 09.05.2021 | Cerro Porteño | - | Club Nacional | 2:2 | ||||
| 16. Jornada | 18.05.2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 | ||||
| 18. Jornada | 31.05.2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 |
Paraguay