| 3. Jornada | 21.01.2022 | Atlético San Luis | - | FC Juárez | 0:1 | ||||
| 4. Jornada | 06.02.2022 | CF América | - | Atlético San Luis | 2:3 | ||||
| 6. Jornada | 20.02.2022 | UANL Tigres | - | Atlético San Luis | 2:1 | ||||
| 7. Jornada | 27.02.2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 12. Jornada | 02.04.2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 14. Jornada | 16.04.2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Jornada | 21.04.2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Jornada | 25.04.2022 | Cruz Azul | - | Atlético San Luis | 0:1 |
México