| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:1 | ||||
| 3. Jornada | 21.01.2022 | Mazatlán FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 |  |
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| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | ||||
| 6. Jornada | 20.02.2022 | Deportivo Toluca [Sub 20] | - | Cruz Azul [Sub 20] | 1:1 | ||||
| 7. Jornada | 24.02.2022 | Gallos Blancos [Sub 20] | - | Deportivo Toluca [Sub 20] | 0:1 | ||||
| 8. Jornada | 01.03.2022 | Deportivo Toluca [Sub 20] | - | Club Tijuana [Sub 20] | 3:1 | ||||
| 9. Jornada | 04.03.2022 | Club Necaxa [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:2 |  |
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| 10. Jornada | 13.03.2022 | Deportivo Toluca [Sub 20] | - | CF Pachuca [Sub 20] | 1:1 | ||||
| 11. Jornada | 20.03.2022 | CF América [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:0 | ||||
| 12. Jornada | 03.04.2022 | Deportivo Toluca [Sub 20] | - | Puebla FC [Sub 20] | 2:0 | |
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| 17. Jornada | 01.05.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:1 |
México