| 5. Jornada | 24.07.2022 | Indy Eleven | - | Memphis 901 | 1:1 | ||||
| 5. Jornada | 31.07.2022 | Indy Eleven | - | Tampa Bay Rowdies | 1:3 |  |
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| 6. Jornada | 07.08.2022 | Indy Eleven | - | Pittsburgh Riverhounds | 0:2 | ||||
| 6. Jornada | 14.08.2022 | Hartford Athletic | - | Indy Eleven | 2:1 | ||||
| 6. Jornada | 21.08.2022 | FC Tulsa | - | Indy Eleven | 1:0 | |
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| 6. Jornada | 28.08.2022 | Indy Eleven | - | San Antonio FC | 1:0 | |
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| 7. Jornada | 01.09.2022 | Indy Eleven | - | Louisville City FC | 2:1 | ||||
| 7. Jornada | 04.09.2022 | Detroit City FC | - | Indy Eleven | 0:0 | ||||
| 7. Jornada | 11.09.2022 | Indy Eleven | - | Birmingham Legion | 4:3 |  |
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| 7. Jornada | 18.09.2022 | Monterey Bay FC | - | Indy Eleven | 5:0 | |
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| 7. Jornada | 25.09.2022 | Indy Eleven | - | Loudoun United | 1:0 | ||||
| 7. Jornada | 29.09.2022 | Atlanta United II | - | Indy Eleven | 0:1 | ||||
| 8. Jornada | 02.10.2022 | Indy Eleven | - | FC Tulsa | 2:4 | ||||
| 8. Jornada | 09.10.2022 | Indy Eleven | - | Charleston Battery | 4:1 | ||||
| 8. Jornada | 13.10.2022 | Birmingham Legion | - | Indy Eleven | 3:1 |
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