| 5. Jornada | 12.02.2022 | Santos Laguna [Sub 20] | - | CF América [Sub 20] | 0:0 | ||||
| 6. Jornada | 18.02.2022 | FC Juárez [Sub 20] | - | Santos Laguna [Sub 20] | 1:2 |  |
|||
| 7. Jornada | 27.02.2022 | Cruz Azul [Sub 20] | - | Santos Laguna [Sub 20] | 2:1 | ||||
| 8. Jornada | 02.03.2022 | Santos Laguna [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 9. Jornada | 05.03.2022 | Deportivo Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 0:0 | ||||
| 10. Jornada | 12.03.2022 | Santos Laguna [Sub 20] | - | Club Tijuana [Sub 20] | 4:2 | ||||
| 11. Jornada | 18.03.2022 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 | ||||
| 13. Jornada | 26.03.2022 | CF Monterrey [Sub 20] | - | Santos Laguna [Sub 20] | 1:2 |
México