| 2. Jornada | 22.01.2022 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 3. Jornada | 29.01.2022 | Saltillo FC | - | Cimarrones de Sonora II | 2:1 | ||||
| 4. Jornada | 05.02.2022 | Correcaminos UAT II | - | Saltillo FC | 1:1 | ||||
| 5. Jornada | 14.02.2022 | Tritones Vallarta | - | Saltillo FC | 2:1 |  |
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| 6. Jornada | 19.02.2022 | Saltillo FC | - | Catedráticos Elite | 3:0 |  |
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| 7. Jornada | 26.02.2022 | Gavilanes de Matamoros | - | Saltillo FC | 1:2 | |
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| 1. Jornada | 02.03.2022 | Saltillo FC | - | Tuzos de la UAZ | 1:0 | |
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| 8. Jornada | 05.03.2022 | Saltillo FC | - | Mazorqueros | 1:5 | ||||
| 9. Jornada | 12.03.2022 | Tecos Fútbol Club | - | Saltillo FC | 1:2 | |
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| 10. Jornada | 19.03.2022 | Saltillo FC | - | Colima FC | 2:1 | |
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| 11. Jornada | 26.03.2022 | Leones Negros II | - | Saltillo FC | 2:1 | ||||
| 13. Jornada | 10.04.2022 | Mineros de Fresnillo FC | - | Saltillo FC | 0:5 | |
México