| 1. Jornada | 14.08.2021 | Floriana FC | - | St. Luċija FC | 2:2 | ||||
| 2. Jornada | 22.08.2021 | St. Luċija FC | - | Gżira United | 1:1 | ||||
| 3. Jornada | 12.09.2021 | Gudja United | - | St. Luċija FC | 2:2 | ||||
| 4. Jornada | 18.09.2021 | St. Luċija FC | - | Sirens FC | 1:3 | ||||
| 5. Jornada | 25.09.2021 | Hibernians FC | - | St. Luċija FC | 1:1 | ||||
| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Jornada | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 |  |
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| 8. Jornada | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 9. Jornada | 21.11.2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | ||||
| 10. Jornada | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Jornada | 05.12.2021 | St. Luċija FC | - | Balzan FC | 3:3 | |
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| 14. Jornada | 19.01.2022 | St. Luċija FC | - | Gudja United | 0:3 | ||||
| 16. Jornada | 29.01.2022 | St. Luċija FC | - | Hibernians FC | 0:0 | ||||
| 17. Jornada | 05.02.2022 | Mosta FC | - | St. Luċija FC | 1:0 |
Malta