| 1. Jornada | 17.07.2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 3. Jornada | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 4. Jornada | 29.07.2022 | Guaireña FC | - | General Caballero DJLM | 1:2 |  |
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| 5. Jornada | 06.08.2022 | General Caballero DJLM | - | Tacuary | 0:4 | ||||
| 6. Jornada | 15.08.2022 | Sportivo Ameliano | - | General Caballero DJLM | 2:0 | ||||
| 7. Jornada | 20.08.2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 8. Jornada | 27.08.2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 | ||||
| 9. Jornada | 03.09.2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 11. Jornada | 17.09.2022 | Sol de América | - | General Caballero DJLM | 3:2 | |
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| 12. Jornada | 19.09.2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 17. Jornada | 16.10.2022 | General Caballero DJLM | - | Sportivo Ameliano | 2:0 | ||||
| 18. Jornada | 23.10.2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
| 19. Jornada | 28.10.2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 | ||||
| 20. Jornada | 01.11.2022 | General Caballero DJLM | - | Resistencia SC | 1:0 | ||||
| 22. Jornada | 13.11.2022 | General Caballero DJLM | - | Sol de América | 0:0 |
Paraguay