| 10. Jornada | 25.09.2021 | CF América [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 5:1 | ||||
| 11. Jornada | 29.09.2021 | Gallos Blancos [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:1 | ||||
| 12. Jornada | 02.10.2021 | Deportivo Guadalajara [Sub 18] | - | Atlas Guadalajara [Sub 18] | 3:0 |  |
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| 15. Jornada | 23.10.2021 | Deportivo Guadalajara [Sub 18] | - | Cruz Azul [Sub 18] | 2:1 | |
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| 16. Jornada | 30.10.2021 | UANL Tigres [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:3 | ||||
| 17. Jornada | 05.11.2021 | Mazatlán FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 2:1 |
México