| 1. Jornada | 03.07.2022 | Pumas UNAM | - | Club Tijuana | 1:1 |  |
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| 2. Jornada | 10.07.2022 | Club León | - | Pumas UNAM | 3:3 | ||||
| 3. Jornada | 17.07.2022 | Pumas UNAM | - | Club Necaxa | 1:0 | ||||
| 4. Jornada | 25.07.2022 | CF Pachuca | - | Pumas UNAM | 0:0 | ||||
| 5. Jornada | 28.07.2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 6. Jornada | 31.07.2022 | Pumas UNAM | - | CF Monterrey | 1:1 | |
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| 8. Jornada | 14.08.2022 | Pumas UNAM | - | CF América | 0:3 | |
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| 10. Jornada | 21.08.2022 | Pumas UNAM | - | Santos Laguna | 1:5 | ||||
| 16. Jornada | 25.08.2022 | Pumas UNAM | - | UANL Tigres | 1:1 | |
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| 11. Jornada | 28.08.2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 13. Jornada | 08.09.2022 | Pumas UNAM | - | Gallos Blancos | 4:1 | ||||
| 14. Jornada | 11.09.2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 | |
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| 7. Jornada | 24.09.2022 | Puebla FC | - | Pumas UNAM | 2:1 | ||||
| 17. Jornada | 01.10.2022 | FC Juárez | - | Pumas UNAM | 3:1 | |
México