| 1. Jornada | 21.08.2021 | SC Buochs | - | FC Solothurn | 0:4 |  |
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| 2. Jornada | 28.08.2021 | FC Solothurn | - | FC Luzern II | 0:1 | ||||
| 3. Jornada | 04.09.2021 | FC Bassecourt | - | FC Solothurn | 2:1 | ||||
| 4. Jornada | 11.09.2021 | FC Solothurn | - | SR Delémont | 1:1 | |
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| 5. Jornada | 18.09.2021 | FC Köniz | - | FC Solothurn | 0:3 | |
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| 6. Jornada | 25.09.2021 | FC Solothurn | - | FC Münsingen | 1:1 | |
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| 7. Jornada | 02.10.2021 | FC Wohlen | - | FC Solothurn | 0:1 | ||||
| 8. Jornada | 16.10.2021 | FC Solothurn | - | Zug 94 | 0:1 | ||||
| 9. Jornada | 24.10.2021 | Grasshopper Club Zürich II | - | FC Solothurn | 2:2 | |
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| 10. Jornada | 30.10.2021 | FC Solothurn | - | FC Schötz | 0:1 | ||||
| 11. Jornada | 07.11.2021 | FC Kosova Zürich | - | FC Solothurn | 4:0 | ||||
| 12. Jornada | 13.11.2021 | FC Solothurn | - | FC Langenthal | 0:2 | ||||
| 13. Jornada | 20.11.2021 | SV Höngg | - | FC Solothurn | 4:0 | ||||
| 14. Jornada | 27.11.2021 | FC Solothurn | - | SC Buochs | 4:2 | |
Suiza