| 1. Jornada | 04.07.2022 | Atlético San Luis | - | Club León | 1:2 |  |
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| 2. Jornada | 10.07.2022 | Club León | - | Pumas UNAM | 3:3 | |
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| 3. Jornada | 16.07.2022 | Puebla FC | - | Club León | 1:1 | |
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| 4. Jornada | 21.07.2022 | Deportivo Guadalajara | - | Club León | 0:0 | ||||
| 5. Jornada | 27.07.2022 | Club León | - | Deportivo Toluca | 0:1 | |
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| 6. Jornada | 01.08.2022 | Club León | - | CF América | 3:2 | ||||
| 7. Jornada | 07.08.2022 | CF Monterrey | - | Club León | 5:1 | ||||
| 8. Jornada | 14.08.2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 9. Jornada | 19.08.2022 | Santos Laguna | - | Club León | 2:1 | ||||
| 10. Jornada | 22.08.2022 | CF Pachuca | - | Club León | 1:0 | ||||
| 11. Jornada | 29.08.2022 | Club León | - | Atlas Guadalajara | 4:2 | |
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| 12. Jornada | 03.09.2022 | Club Necaxa | - | Club León | 3:2 | ||||
| 13. Jornada | 07.09.2022 | Club León | - | FC Juárez | 1:0 | |
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| 14. Jornada | 11.09.2022 | UANL Tigres | - | Club León | 0:1 | |
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| 16. Jornada | 16.09.2022 | Cruz Azul | - | Club León | 2:1 | ||||
| 15. Jornada | 19.09.2022 | Club León | - | Gallos Blancos | 3:1 | |
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| 17. Jornada | 03.10.2022 | Club León | - | Club Tijuana | 2:2 | |
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