| 1. Jornada | 11.09.2021 | Cerro Largo | - | Nacional | 0:3 |  |
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| 2. Jornada | 18.09.2021 | Cerrito | - | Cerro Largo | 1:1 |  |
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| 3. Jornada | 25.09.2021 | Cerro Largo | - | Liverpool | 3:0 | |
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| 4. Jornada | 02.10.2021 | River Plate | - | Cerro Largo | 0:4 | |
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| 5. Jornada | 09.10.2021 | Cerro Largo | - | Deportivo Maldonado | 1:1 | |
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| 6. Jornada | 17.10.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 7. Jornada | 21.10.2021 | Sud América | - | Cerro Largo | 0:0 | ||||
| 10. Jornada | 04.11.2021 | Cerro Largo | - | Boston River | 1:1 | |
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| 11. Jornada | 08.11.2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | |
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| 12. Jornada | 15.11.2021 | Cerro Largo | - | Rentistas | 1:1 | |
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| 13. Jornada | 23.11.2021 | Peñarol | - | Cerro Largo | 2:2 | |
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| 14. Jornada | 29.11.2021 | Cerro Largo | - | Montevideo City Torque | 1:1 | ||||
| 15. Jornada | 05.12.2021 | Villa Española | - | Cerro Largo | 1:1 | |
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